Das Basanta K, Srinives Sira, Mulchandani Ashok
Appl Phys Lett. 2011 Jan 3;98(1):13701. doi: 10.1063/1.3529951. Epub 2011 Jan 4.
We fabricated ZnS nanocrystals decorated single-walled carbon nanotube (SWNT) based chemiresistive sensor for DNA. Since the charge transfer in the hybrid nanostructures is considered to be responsible for many of their unique properties, the role of ZnS nanocrystals toward its performance in DNA sensor was delineated. It was found that the free carboxyl groups surrounding the ZnS nanocrystals allowed large loading of single strand DNA (ssDNA) probe that provided an ease of hybridization with target complementary c-ssDNA resulting in large electron transfer to SWNT. Thus it provided a significant improvement in sensitivity toward c-ssDNA as compared to bare SWNT based DNA sensor.
我们制备了基于硫化锌（ZnS）纳米晶体修饰的单壁碳纳米管（SWNT）的DNA化学电阻传感器。由于混合纳米结构中的电荷转移被认为是其许多独特性质的原因，因此阐述了ZnS纳米晶体在DNA传感器中的性能作用。结果发现，ZnS纳米晶体周围的游离羧基允许大量加载单链DNA（ssDNA）探针，这便于与目标互补c-ssDNA杂交，从而导致大量电子转移到SWNT。因此，与基于裸SWNT的DNA传感器相比，它对c-ssDNA的灵敏度有了显著提高。
