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本文引用的文献

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Tumor antigen presentation by dendritic cells.树突状细胞对肿瘤抗原的呈递。
Crit Rev Immunol. 2010;30(4):345-86. doi: 10.1615/critrevimmunol.v30.i4.30.
2
Magnetic nanoparticles for imaging dendritic cells.用于成像树突状细胞的磁性纳米颗粒。
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Dendritic cells: therapy and imaging.树突状细胞：治疗与成像。
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A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors.一项关于MUC1肽脉冲自体树突状细胞疫苗作为辅助治疗切除的胰腺和胆管肿瘤患者的I/II期研究。
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Cancer immunology.癌症免疫学
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Tracking the migration of dendritic cells by in vivo optical imaging.通过体内光学成像追踪树突状细胞的迁移。
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7
MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model.在MUC1耐受的结肠癌模型中，MUC1特异性免疫疗法可产生强烈的抗肿瘤反应。
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Immune responses in the draining lymph nodes against cancer: implications for immunotherapy.引流淋巴结中针对癌症的免疫反应：对免疫治疗的启示。
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Delivery of tumor associated antigens to antigen presenting cells using penetratin induces potent immune responses.使用穿膜肽将肿瘤相关抗原递送至抗原呈递细胞可诱导强烈的免疫反应。
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In vivo imaging of tumor response to therapy using a dual-modality imaging strategy.使用双模态成像策略对肿瘤治疗反应进行体内成像。
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树突状细胞负载跨膜黏蛋白 1 肽抗原诱导抗肿瘤免疫。

Induction of antitumor immunity by dendritic cells loaded with membrane-translocating mucin 1 Peptide antigen.

机构信息

Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.

出版信息

Transl Oncol. 2011 Feb 1;4(1):1-8. doi: 10.1593/tlo.10166.

DOI:10.1593/tlo.10166
PMID:21286372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3026404/
Abstract

To investigate the role of enhanced antigen presentation in dendritic cell (DC)-based immunotherapy. Here, we describe the development of a cell-penetrating mucin 1 (MUC1) antigen and its immunotherapeutic potential against tumors. After animal groups received two immunizations of MUC1-MPA(11)P-pulsed DCs, we observed a marked tumor regression compared with the mice treated with DCs alone or DCs pulsed with MUC1 peptide. We confirmed the migration and homing of DCs in the popliteal lymph node using magnetic resonance imaging during the study. In summary, enhanced antigen uptake using an MPA(11)P delivery molecule improves cell therapy.

摘要

为了研究增强的抗原提呈在树突状细胞（DC）为基础的免疫疗法中的作用。在这里，我们描述了一种穿透细胞的粘蛋白 1（MUC1）抗原的开发及其针对肿瘤的免疫治疗潜力。在动物组接受两次 MUC1-MPA(11)P 脉冲 DC 免疫接种后，与单独用 DC 或用 MUC1 肽脉冲的 DC 治疗的小鼠相比，我们观察到肿瘤明显消退。在研究过程中，我们使用磁共振成像确认了 DC 在腘淋巴结中的迁移和归巢。总之，使用 MPA(11)P 递药分子增强抗原摄取可改善细胞治疗。