Vanderbilt University, Institute of Imaging Science, Nashville, TN 37232-2310, USA.
Expert Opin Biol Ther. 2009 May;9(5):539-64. doi: 10.1517/14712590902867739.
Dendritic cells (DCs) play a major role in cell-mediated immunotherapy. In this approach, DCs are isolated from cancer patients and pulsed with exogenous and specific tumor antigens in vitro, and the antigen-loaded DCs are then transferred to the hosts to enhance the immune response against tumor targets. Clinical observations and animal studies have shown that tumors can elicit immune responses caused by tumor infiltration of T-lymphocytes. Several pilot clinical trials have been recently conducted using this strategy for treating several types of cancers.
To optimize DC-based therapy with emerging molecular imaging techniques.
A review of the most current literature on DCs and imaging work.
RESULTS/CONCLUSION: The translational application of DC-based therapy can be supported greatly through molecular imaging. New discoveries on DC migration and behavior in vivo will lead to new advances in the treatment of a broad range of cancers.
树突状细胞（DCs）在细胞介导的免疫治疗中起着重要作用。在这种方法中，从癌症患者中分离出 DCs，然后在体外与外源性和特异性肿瘤抗原孵育，再将负载抗原的 DC 转移到宿主中，以增强对肿瘤靶标的免疫反应。临床观察和动物研究表明，肿瘤可以引发由 T 淋巴细胞浸润肿瘤引起的免疫反应。最近已经进行了几项使用这种策略治疗多种癌症的试点临床试验。
利用新兴的分子成像技术优化基于 DC 的治疗。
对 DC 和成像工作的最新文献进行综述。
结果/结论：通过分子成像可以极大地支持基于 DC 的治疗的转化应用。对 DC 在体内迁移和行为的新发现将推动广泛的癌症治疗的新进展。
