用于阿霉素药物递送的 DNA 封端纳米颗粒。
DNA-capped nanoparticles designed for doxorubicin drug delivery.
机构信息
Department of Chemistry, Syracuse University, 111 College Pl., Syracuse, NY 13244-4100, USA.
出版信息
Chem Commun (Camb). 2011 Mar 28;47(12):3418-20. doi: 10.1039/c0cc04916f. Epub 2011 Feb 1.
PMID:21286626
Abstract
The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.
摘要
抗癌药物阿霉素（DOX）被负载到设计用于特定 DOX 嵌入的 DNA 封端的金纳米粒子（AuNP）上。通过监测 DNA 熔点、AuNP 等离子体共振最大值和水动力半径的增加，作为[DOX]/[DNA]比的函数，证实了药物结合。证实了药物向靶 DNA 释放的能力。
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