过氧化物酶体增殖物激活受体α（PPARα）和过氧化物酶体增殖物激活受体γ共激活因子-1α（PGC-1α）对糖尿病心脏代谢的调节
Peroxisome proliferator activated receptor-alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes.
作者信息
Duncan Jennifer G
机构信息
Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8208, St Louis, MO 63110, USA.
出版信息
Pediatr Cardiol. 2011 Mar;32(3):323-8. doi: 10.1007/s00246-011-9889-8. Epub 2011 Feb 2.
Abstract
Cardiovascular disease is a leading cause of mortality among patients with diabetes, and heart failure exists even in the absence of coronary disease. Myocardial metabolism is altered in the diabetic heart as a result of changes in substrate availability secondary to insulin resistance. The nuclear receptor peroxisome proliferator activated receptor-alpha (PPARα) and PPAR-gamma coactivator-1alpha (PGC-1α) play important roles in transcriptional regulation of myocardial metabolism and contribute significantly to the changes that occur in the diabetic heart. This review summarizes the role of PPARα and PGC-1α in myocardial metabolism in the normal heart and in the diabetic heart.
摘要
心血管疾病是糖尿病患者死亡的主要原因，即使在没有冠心病的情况下也会出现心力衰竭。由于胰岛素抵抗导致底物可用性改变，糖尿病心脏中的心肌代谢发生改变。核受体过氧化物酶体增殖物激活受体α（PPARα）和PPARγ共激活因子-1α（PGC-1α）在心肌代谢的转录调节中起重要作用，并对糖尿病心脏中发生的变化有显著影响。本文综述了PPARα和PGC-1α在正常心脏和糖尿病心脏心肌代谢中的作用。
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