Hashemi Mohammad, Zakeri Zahra, Eskandari-Nasab Ebrahim, Atabaki Mahdi, Pourhosseini Seyed Mohammad Ebrahim, Jahantigh Mehdi, Bahari Gholamreza, Taheri Mohsen
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Dept. of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Iran Biomed J. 2013;17(4):194-9. doi: 10.6091/ibj.1205.2013.
Rheumatoid arthritis (RA) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. The aim of the present study was to investigate the impact of CD226 rs727088 and rs763361 polymorphisms and susceptibility to RA in a sample of the Iranian population.
This case-control study was carried out on 100 patients with RA and 104 healthy subjects. The polymorphisms were determined using tetra amplification refractory mutation system-polymerase chain reaction assay.
The rs763361 (Gly307Ser) polymorphism increased the risk of RA in codominant, dominant and recessive-tested inheritance models (odds ratio [OR] = 3.18, 95% confidence intervals [95% CI] = 1.44-7.02, P = 0.004, CC vs. TT, and OR = 1.98, 95% CI = 1.10-3.57, P = 0.023, CC vs. CT-TT, and OR = 2.61, 95% CI = 1.26-5.37, P = 0.010, CC + CT vs. TT, respectively). In addition, the rs763361 T allele increased the risk of RA (OR = 2.06, 95% CI = 1.38-3.08, P<0.001). However, no significant difference was observed among the groups regarding CD226 rs727088 polymorphism (χ2 = 3.20, P = 0.202).
Our finding showed that CD226 rs763361, but not rs727088, gene polymorphism increased the risk of RA in a sample of the Iranian population.
类风湿关节炎（RA）是一种慢性炎症性疾病，有许多遗传因素易导致疾病易感性。本研究的目的是在伊朗人群样本中调查CD226基因rs727088和rs763361多态性对RA易感性的影响。
本病例对照研究对100例RA患者和104名健康受试者进行。使用四重扩增阻滞突变系统-聚合酶链反应分析法确定多态性。
rs763361（Gly307Ser）多态性在共显性、显性和隐性遗传模型中增加了RA的风险（优势比[OR]=3.18，95%置信区间[95%CI]=1.44-7.02，P=0.004，CC与TT相比；OR=1.98，95%CI=1.10-3.57，P=0.023，CC与CT-TT相比；OR=2.61，95%CI=1.26-5.37，P=0.010，CC+CT与TT相比）。此外，rs763361的T等位基因增加了RA的风险（OR=2.06，95%CI=1.38-3.08，P<0.001）。然而，在CD226 rs727088多态性方面，各组之间未观察到显著差异（χ2=（此处可能有误，原文应为卡方值，未给出具体数值）3.20，P=0.202）。
我们的研究结果表明，在伊朗人群样本中，CD226基因rs763361而非rs727088的基因多态性增加了RA的风险。
