Department of Rheumatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Clin Rheumatol. 2011 Jun;30(6):859-65. doi: 10.1007/s10067-011-1689-2. Epub 2011 Feb 1.
Kimura's disease (KD) is a rare, benign, chronic inflammatory disease which typically presents as persisting or recurring tumor-like lesions in the head and neck area that can be easily misdiagnosed. We report one patient with KD treated with leflunomide in combination with glucocorticoids and analyzed the literature on treatment of KD. The patient had a recurrent mass in the left upper arm with eosinophilia and elevated serum IgE but no renal involvement. The clinical manifestations improved markedly within 1 month, and blood eosinophil count and serum IgE normalized. Corticosteroids were then tapered gradually without recurrence or severe side effects in the 2-year follow-up period. Literature analysis identified four different non-drug interventions and 18 different drugs for treating KD, most of which were obtained from case reports. Our use of combination therapy of leflunomide and glucocorticoids suggests the need for a controlled trial for the treatment of this rare disorder.
木村病（KD）是一种罕见的良性慢性炎症性疾病，通常表现为头颈部持续或反复出现类似肿瘤的病变，容易误诊。我们报告一例 KD 患者接受来氟米特联合糖皮质激素治疗，并对 KD 的治疗进行文献分析。患者左上臂反复出现肿块，伴有嗜酸性粒细胞增多和血清 IgE 升高，但无肾脏受累。1 个月内临床症状明显改善，血嗜酸性粒细胞计数和血清 IgE 恢复正常。在 2 年的随访期间，逐渐减少皮质类固醇用量，无复发或严重不良反应。文献分析发现了四种不同的非药物干预措施和 18 种不同的治疗 KD 的药物，其中大部分来自病例报告。我们使用来氟米特和糖皮质激素联合治疗的方法提示需要进行对照试验来治疗这种罕见疾病。
