Sun Chuanyin, Ni Haopeng, Jiang Mengdi, Wang Guolin, Su Xinhui, Liu Zhenfeng
Department of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People's Republic of China.
Zhejiang University School of Medicine, Hangzhou, Zhejiang, 3100058, People's Republic of China.
J Inflamm Res. 2025 May 21;18:6483-6488. doi: 10.2147/JIR.S513892. eCollection 2025.
Kimura's disease is a rare, chronic inflammatory disorder characterized by subcutaneous nodules, eosinophilia, and elevated serum IgE levels. It commonly affects young Asian males and typically presents in the head and neck region. Diagnosis is confirmed via histopathological examination, while treatment options include corticosteroids, surgery, and radiotherapy. [F]AlF-NOTA-FAPI-04 PET/CT demonstrated superior imaging, with clearer background and higher target-to-background ratio, highlighting lesions with higher SUV values and greater specificity for fibroblast activity. Compared to F-FDG PET/CT, which is limited by nonspecific uptake in inflammatory tissues, [F]AlF-NOTA-FAPI-04 PET/CT offers superior sensitivity and specificity in visualizing fibroblast activation. These advantages not only improve diagnostic accuracy in Kimura's disease but may also have broader implications for other eosinophilic or inflammatory disorders sharing similar clinical features. This technique improves diagnostic accuracy, facilitates treatment planning, and may guide the development of future treatment.
木村病是一种罕见的慢性炎症性疾病，其特征为皮下结节、嗜酸性粒细胞增多和血清IgE水平升高。它通常影响年轻亚洲男性，典型表现部位为头颈部。通过组织病理学检查确诊，治疗选择包括使用皮质类固醇、手术和放疗。[F]AlF-NOTA-FAPI-04 PET/CT显示出更好的成像效果，背景更清晰，靶本比更高，突出了SUV值更高且对成纤维细胞活性具有更高特异性的病变。与受炎症组织中非特异性摄取限制的F-FDG PET/CT相比，[F]AlF-NOTA-FAPI-04 PET/CT在显示成纤维细胞活化方面具有更高的敏感性和特异性。这些优势不仅提高了木村病的诊断准确性，对具有相似临床特征的其他嗜酸性或炎症性疾病可能也有更广泛的意义。该技术提高了诊断准确性，有助于治疗方案的制定，并可能为未来治疗的发展提供指导。
