Obata Yoko, Furusu Akira, Nishino Tomoya, Ichinose Hiroshi, Ohnita Aki, Iwasaki Keisuke, Taguchi Takashi, Kohno Shigeru
The Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
Intern Med. 2010;49(14):1405-9. doi: 10.2169/internalmedicine.49.2977. Epub 2010 Jul 15.
We report a case of Kimura's disease with membranous nephropathy. A 15-year-old Japanese boy was referred to our hospital with proteinuria and a subcutaneous mass in the hip. Renal biopsy demonstrated secondary membranous nephropathy (MN) with mild mesangial proliferation and some electron-dense deposits in the mesangium. Laboratory tests revealed eosinophilia and a high level of serum IgE, which are common findings in Kimura's disease. A biopsy of the mass in the hip was performed and Kimura's disease was diagnosed. Treatment with oral prednisolone resulted in a decrease of proteinuria and regression of the subcutaneous mass. Kimura's disease should be included in the differential diagnosis of secondary MN.
我们报告一例伴膜性肾病的木村病。一名15岁日本男孩因蛋白尿和髋部皮下肿块转诊至我院。肾活检显示为继发性膜性肾病（MN），伴有轻度系膜增生和系膜区一些电子致密沉积物。实验室检查显示嗜酸性粒细胞增多和血清IgE水平升高，这是木村病的常见表现。对髋部肿块进行活检，诊断为木村病。口服泼尼松龙治疗导致蛋白尿减少和皮下肿块消退。木村病应纳入继发性MN的鉴别诊断。
