The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany St, New Brunswick, NJ 08903, USA.
Cancer Causes Control. 2011 Apr;22(4):563-71. doi: 10.1007/s10552-011-9728-5. Epub 2011 Feb 1.
The evidence for a role of diet on ovarian cancer prevention remains inconclusive. While many studies have evaluated individual foods and food groups, the evaluation of a comprehensive dietary quality index for predicting cancer risk has received little attention. This study investigates the association between the Healthy Eating Index (HEI), which reflects adherence to the current USDA Dietary Guidelines for Americans and ovarian cancer risk in a population-based case-control study in New Jersey. A total of 205 cases and 390 controls completed the Block 98.2 food frequency questionnaire (FFQ) in addition to reporting on potential risk factors for ovarian cancer. FFQ data were then utilized to calculate the HEI score, and cup, ounce, gram, or caloric equivalents for the 12 different food groups comprising the index. In multivariate models, the OR for the highest tertile of the HEI score compared with the lowest (reflecting a better diet compared with a worse diet) was 0.90 (95% CI: 0.55-1.47). There was limited evidence for a statistically significant association between any of the 12 individual food components and ovarian cancer risk. Based on this study's results, neither individual food groups nor dietary quality showed potential for preventing ovarian cancer.
关于饮食在卵巢癌预防中的作用的证据仍然没有定论。虽然许多研究已经评估了个别食物和食物组，但对于预测癌症风险的综合饮食质量指数的评估却很少受到关注。本研究在新泽西州进行的一项基于人群的病例对照研究中，调查了健康饮食指数（HEI）与卵巢癌风险之间的关联，该指数反映了对当前美国农业部美国人饮食指南的遵守情况。共有 205 例病例和 390 例对照者完成了 Block 98.2 食物频率问卷（FFQ），此外还报告了卵巢癌的潜在风险因素。然后利用 FFQ 数据计算 HEI 评分，以及构成该指数的 12 种不同食物组的杯、盎司、克或卡路里当量。在多变量模型中，与最低 HEI 评分 tertile 相比，最高 tertile 的 OR（反映与较差饮食相比更好的饮食）为 0.90（95%CI：0.55-1.47）。任何 12 种单个食物成分与卵巢癌风险之间的统计学显著关联的证据都很有限。基于本研究的结果，无论是单个食物组还是饮食质量都没有显示出预防卵巢癌的潜力。
