Josephine Bay Paul Center, The Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA.
Chromosome Res. 2011 Apr;19(3):367-76. doi: 10.1007/s10577-011-9186-7.
The notion of nucleic acids in the spindle, and particularly, the centrosome has a long history of inquiry, doubt, and debate. However, the association of specific RNAs with these structures is now confirmed by several investigators. What their presence means for the assembly, function, and evolution of the cell division apparatus is not known; but with newly available information and probes, these are questions that can finally be addressed. The present article summarizes the history of this field, what we know about the molecules in question, and in light of these findings, emphasizes the need to view the cell division apparatus for what it is by definition, a ribonucleoprotein complex.
纺锤体中核酸的概念，特别是中心体，长期以来一直是研究、怀疑和争论的主题。然而，现在有几位研究人员已经证实了特定的 RNA 与这些结构的关联。它们的存在对细胞分裂装置的组装、功能和进化意味着什么还不得而知；但是，随着新的可用信息和探针的出现，这些问题终于可以得到解决。本文总结了这一领域的历史，介绍了有关分子的现有知识，并根据这些发现，强调需要从定义上把细胞分裂装置看作是一个核糖核蛋白复合物。
