The First Hospital of Jilin University, 71 Xinmin Road, Changchun, 130021, People's Republic of China.
Inflammation. 2012 Feb;35(1):114-21. doi: 10.1007/s10753-011-9295-7.
Hesperidin, a flavanone glycoside comprised of the flavanone hesperetin and the disaccharide rutinose, is a plentiful and inexpensive by-product of citrus cultivation. It has been reported to exert a wide range of pharmacological effects that include antioxidant, anti-inflammatory, and anticarcinogenic properties. In this study, we attempt to determine whether hesperidin inhibits inflammatory mediators in the mouse allergic asthma model. Mice were sensitized and challenged by ovalbumin (OVA) to induce chronic airway inflammation and airway remodeling. The administration of hesperidin significantly decreased the number of infiltrating inflammatory cells and Th2 cytokines in bronchoalveolar lavage (BAL) fluid compared with the OVA-induced group of mice. In addition, hesperidin reduced OVA-specific IgE levels in serum. Hesperidin markedly alleviated the OVA-induced airway hyperresponsiveness (AHR) to inhaled methacholine. Based on lung histopathological studies using hematoxylin and eosin and alcian blue-periodic acid-Schiff staining, hesperidin inhibited inflammatory cell infiltration and mucus hypersecretion compared with the OVA-induced group of mice. These findings provide new insight into the immunopharmacological role of hesperidin in terms of its effects in a murine model of asthma.
橙皮苷是一种由黄酮橙皮素和二糖芦丁组成的类黄酮糖苷，是柑橘种植的丰富且廉价的副产品。它已被报道具有广泛的药理作用，包括抗氧化、抗炎和抗癌特性。在本研究中，我们试图确定橙皮苷是否抑制小鼠过敏性哮喘模型中的炎症介质。通过卵清蛋白（OVA）致敏和攻击小鼠，诱导慢性气道炎症和气道重塑。与 OVA 诱导组相比，橙皮苷给药显著减少了支气管肺泡灌洗液（BAL）中浸润的炎症细胞和 Th2 细胞因子的数量。此外，橙皮苷降低了血清中 OVA 特异性 IgE 水平。橙皮苷显著减轻了 OVA 诱导的气道高反应性（AHR）对吸入乙酰甲胆碱的反应。基于苏木精和伊红以及粘蛋白酸性蓝-过碘酸-希夫染色的肺组织病理学研究，与 OVA 诱导组相比，橙皮苷抑制了炎症细胞浸润和粘液分泌过度。这些发现为橙皮苷在哮喘小鼠模型中的免疫药理学作用提供了新的见解。
