Almeida Luara B, Segurado Aluisio C, Duran Ana Clara F, Jaime Patricia C
School of Public Health, University of Sao Paulo, Avenida Doutor Arnaldo, São Paulo, Brazil.
AIDS Care. 2011 Jun;23(6):755-63. doi: 10.1080/09540121.2010.525789.
The advent of highly active antiretroviral therapy (HAART) improved HIV infection prognosis. However, adverse metabolic and morphologic effects emerged, highlighting a lack of investigation into the role of nutritional interventions among this population. The present study evaluated the impact of a nutritional counseling program on prevention of morphologic and metabolic changes in patients living with HIV/AIDS receiving HAART. A 12-month randomized clinical trial was conducted with 53 adults of both genders in use of HAART. Subjects were allocated to either an intervention group (IG) or a control group (CG). Nutritional counseling was based on the promotion of a healthy diet pattern. Anthropometrical, biochemical, blood pressure, and food intake variables were assessed on four separate occasions. Sub scapular skin-fold results showed a significant tendency for increase between time 1 (Mean IG = 14.9 mm; CG = 13.6 mm), time 3 (Mean IG = 16.7 mm; CG = 18.2 mm), and time 4 (Mean IG = 16.4 mm; CG = 17.7 mm). Lipid percentage intake presented a greater increase among controls (time 1 mean = 26.3%, time 4 mean = 29.6%) than among IG subjects (time 1 mean = 29.1%, time 4 mean = 28.9%). Moreover, participants allocated to the IG presented an increase in dietetic fiber intake of almost 10 grams. The proposed nutritional counseling program proved to be effective in improving diet by reducing fat consumption and increasing fiber intake.
高效抗逆转录病毒疗法（HAART）的出现改善了HIV感染的预后。然而，不良的代谢和形态学影响出现了，这凸显了对该人群营养干预作用缺乏研究。本研究评估了营养咨询项目对接受HAART的HIV/AIDS患者形态学和代谢变化预防的影响。对53名正在使用HAART的成年男女进行了一项为期12个月的随机临床试验。受试者被分配到干预组（IG）或对照组（CG）。营养咨询基于促进健康饮食模式。在四个不同时间点评估人体测量学、生化、血压和食物摄入变量。肩胛下皮肤褶厚度结果显示，在第1次（干预组均值 = 14.9毫米；对照组 = 13.6毫米）、第3次（干预组均值 = 16.7毫米；对照组 = 18.2毫米）和第4次（干预组均值 = 16.4毫米；对照组 = 17.7毫米）测量时，有显著的增加趋势。脂质摄入百分比在对照组中增加幅度更大（第1次均值 = 26.3%，第4次均值 = 29.6%），高于干预组受试者（第1次均值 = 29.1%，第4次均值 = 28.9%）。此外，分配到干预组的参与者膳食纤维摄入量增加了近10克。所提议的营养咨询项目被证明通过减少脂肪消耗和增加纤维摄入量来改善饮食是有效的。
