青蒿素及其衍生物对厌氧菌的抗菌活性。
Antimicrobial activity of artemisinin and its derivatives against anaerobic bacteria.
作者信息
Shoeb H A, Tawfik A F, Shibl A M, el-Feraly F S
机构信息
Department of Pharmaceutics and Microbiology, College of Pharmacy, King Saud University, Saudi Arabia.
出版信息
J Chemother. 1990 Dec;2(6):362-7. doi: 10.1080/1120009x.1990.11739044.
Artemisinin and nine of its semisynthetic derivatives were tested for antibacterial activity against anaerobic, facultative anaerobic, microaerophilic and aerobic bacteria. Only anaerobic bacteria and gonococci showed sensitivity to artemisinin derivatives. Artemisinin and its deoxy derivatives had no activity at 100 micrograms/ml concentration. The newly synthesized methyl diperoxy derivative had the highest activity against all tested anaerobes with a MIC of 9.4 micrograms/ml.
对青蒿素及其九种半合成衍生物进行了针对厌氧菌、兼性厌氧菌、微需氧菌和好氧菌的抗菌活性测试。只有厌氧菌和淋球菌对青蒿素衍生物表现出敏感性。青蒿素及其脱氧衍生物在浓度为100微克/毫升时无活性。新合成的甲基双氧衍生物对所有测试厌氧菌的活性最高，最低抑菌浓度为9.4微克/毫升。
Zotero 插件