Jones R N, Gerlach E H
Antimicrob Agents Chemother. 1985 Mar;27(3):413-5. doi: 10.1128/AAC.27.3.413.
HR810 and four other new beta-lactams were tested against 419 recent clinical anaerobic bacterial isolates. HR810 was found to have an antimicrobial spectrum most similar to that of cefotaxime, inhibiting 52.6% of Bacteroides fragilis group strains and 97.2% of all other anaerobic strains at an MIC of less than or equal to 16 micrograms/ml. Cefoxitin was found to have a narrower antimicrobial spectrum against the gram-positive anaerobic bacteria (8.4 to 10.1% less) than HR810 and cefotaxime, respectively.
对HR810和其他四种新型β-内酰胺类药物针对419株近期临床分离的厌氧细菌进行了测试。结果发现，HR810的抗菌谱与头孢噻肟最为相似，在最低抑菌浓度小于或等于16微克/毫升时，对脆弱拟杆菌群菌株的抑制率为52.6%，对所有其他厌氧菌株的抑制率为97.2%。发现头孢西丁对革兰氏阳性厌氧细菌的抗菌谱比HR810和头孢噻肟分别窄（少8.4%至10.1%）。
