Liu Hai-bo, Shi Yu-ping, Guo Xiao-fang, Shan Jiang, Xu Geng
Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009 PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Feb;28(1):60-3. doi: 10.3760/cma.j.issn.1003-9406.2011.01.014.
To assess the association of haptoglobin (HP)1/2 polymorphism with coronary heart disease (CHD) in Chinese Hans.
One hundred and eighty-nine CHD patients and 242 healthy controls confirmed with angiography were recruited. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was utilized to genotype the HP1 and HP2 alleles and genotype frequencies in cases and controls were compared.
The frequency of HP2-2 genotype was significantly higher in CHDs than in controls (0.54 vs.0.35, P = 0.000). The HP2-2 genotype significantly increased the risk for CHD in univariable analysis (OR = 2.166, 95%CI: 1.467-3.196). Multifactor Logistic regression analysis indicated that HP2-2 genotype is an independent risk factor to CHD (P = 0.002; OR = 2.101, 95%CI: 1.311-3.367). Similarly, the HP2 allele frequency in the CHD group was significantly higher than that in the control subjects (0.74 vs.0.61, P = 0.000).
The HP2-2 genotype is associated with CHD in Chinese. HP2-2 genotype may be an independent risk factor to CHD, and HP2 allele may be a genetic susceptibility factor to CHD in Chinese.
评估中国汉族人群中触珠蛋白（HP）1/2基因多态性与冠心病（CHD）的关联。
招募了189例经血管造影确诊的冠心病患者和242例健康对照者。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对HP1和HP2等位基因进行基因分型，并比较病例组和对照组的基因型频率。
冠心病患者中HP2-2基因型频率显著高于对照组（0.54对0.35，P = 0.000）。单因素分析中，HP2-2基因型显著增加了冠心病风险（OR = 2.166，95%CI：1.467 - 3.196）。多因素Logistic回归分析表明，HP2-2基因型是冠心病的独立危险因素（P = 0.002；OR = 2.101，95%CI：1.311 - 3.367）。同样，冠心病组中HP2等位基因频率显著高于对照组（0.74对0.61，P = 0.000）。
在中国人群中，HP2-2基因型与冠心病相关。HP2-2基因型可能是冠心病的独立危险因素，而HP2等位基因可能是中国人冠心病的遗传易感性因素。
