[细胞间黏附分子-1基因K469E多态性与冠心病的相关性]
[The correlation between ICAM-1 gene K469E polymorphism and coronary heart disease].
作者信息
Zhang Shun-rong, Xu Li-xin, Gao Qiu-qi, Zhang Huai-qin, Xu Bing-sen, Lin Jie, Huang Wei-jian
机构信息
Department of Cardiovascular Medicine, First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, 325027 P.R.China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Apr;23(2):205-7.
OBJECTIVE
To investigate the correlation between intercellular adhesion molecule1 (ICAM1) gene K469E polymorphism and coronary heart disease(CHD) in Han Chinese population.
METHODS
Using the methods of polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP), 173 CHD patients and 141 controls were analyzed for the polymorphism, genotype and allele distribution of ICAM1 gene K469E.
RESULTS
The distribution of ICAM1 genotypes was in Hardy-Weinberg equilibrium. The frequency of KK genotype in CHD group was significantly higher than that in control (64.2% vs 48.9%, P<0.01). Similarly, the frequency of K allele in CHD group was significantly higher than that in control (79.2% vs 69.9%, P<0.01). With Logistic Regression Analysis ruling out the influences of age, gender and other CHD risk factor, the homozygous individual with KK genotype was 2.35 folds of KE or EE genotype one suffering from CHD (OR: 2.35, 95%CI: 1.03-5.36, P<0.05).
CONCLUSION
ICAM1 gene K469E polymorphism is associated with CHD risk of Han Chinese population, the K allele may serve as a genetic risk factor of coronary heart disease.
目的
探讨汉族人群细胞间黏附分子1（ICAM1）基因K469E多态性与冠心病（CHD）的相关性。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法，分析173例冠心病患者和141例对照者ICAM1基因K469E的多态性、基因型及等位基因分布。
结果
ICAM1基因型分布符合Hardy-Weinberg平衡。冠心病组KK基因型频率显著高于对照组（64.2%对48.9%，P<0.01）。同样，冠心病组K等位基因频率显著高于对照组（79.2%对69.9%，P<0.01）。经Logistic回归分析排除年龄、性别及其他冠心病危险因素的影响后，KK基因型纯合个体患冠心病的风险是KE或EE基因型个体的2.35倍（OR：2.35，95%CI：1.03-5.36，P<0.05）。
结论
ICAM1基因K469E多态性与汉族人群冠心病风险相关，K等位基因可能是冠心病的遗传危险因素。
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