El Haj A J, Cartmell S H
Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, UK.
Proc Inst Mech Eng H. 2010 Dec;224(12):1523-32. doi: 10.1243/09544119JEIM802.
Engineering bone tissue for use in orthopaedics poses multiple challenges. Providing the appropriate growth environment that will allow complex tissues such as bone to grow is one of these challenges. There are multiple design factors that must be considered in order to generate a functional tissue in vitro for replacement surgery in the clinic. Complex bioreactors have been designed that allow different stress regimes such as compressive, shear, and rotational forces to be applied to three-dimensional (3D) engineered constructs. This review addresses these considerations and outlines the types of bioreactor that have been developed and are currently in use.
制造用于骨科的骨组织面临多重挑战。提供合适的生长环境以使诸如骨这样的复杂组织生长就是其中一项挑战。为了在体外生成用于临床置换手术的功能性组织，必须考虑多个设计因素。已经设计出了复杂的生物反应器，其能够将不同的应力状态（如压缩力、剪切力和旋转力）施加于三维（3D）工程构建体上。本综述阐述了这些注意事项，并概述了已开发且目前正在使用的生物反应器类型。
