Teixeira Rodrigues A, Ensina L F Chiaverini, Sabino Garro L, Kase Tanno L, Giavina-Bianchi P, Motta A Abilio
Clinical Immunology and Allergy Service, Department of Internal Medicine, Hospital das Clínicas, University of São Paulo, Brazil.
Eur Ann Allergy Clin Immunol. 2010 Dec;42(6):221-3.
Insulin allergy was not uncommon in the past, but has lowered with the introduction of human recombinant insulin. Human recombinant insulin allergy is a rare condition, now reported in less than 1% of treated patients. However, it is a serious condition that requires an immediate allergological work-up. In this study, we describe 4 cases of IgE-mediated reaction to human recombinant insulin, emphasizing some practical aspects in diagnosis and treatment.
胰岛素过敏在过去并不罕见，但随着人重组胰岛素的引入，其发生率已有所降低。人重组胰岛素过敏是一种罕见情况，目前在接受治疗的患者中报告的发生率不到1%。然而，这是一种严重情况，需要立即进行过敏专科检查。在本研究中，我们描述了4例对人重组胰岛素的IgE介导反应，强调了诊断和治疗中的一些实际问题。
