Weinberg H, Wong P K, Crisp D, Johnson B, Cheyne D
Brain Behaviour Laboratory, Simon Fraser University, Burnaby, B.C., Canada.
Brain Topogr. 1990 Fall;3(1):183-90. doi: 10.1007/BF01128875.
The clinical literature has suggested that while the clinical features and presentation of benign rolandic epilepsy in children (BREC) are known, the neuronal mechanism of the epileptic focus is poorly understood. Classification of clinical subtypes is usually made by determining whether there are supplementary clinical signs of brain damage, in which case the epilepsy is classified as non-benign or "atypical". Studies of EEG findings in BREC have suggested that the source of the epilepsy is in the Rolandic fissure. We investigated dipole source modelling in 24 children, comparing the results of one and two dipole models. The results indicate that atypical BREC patients have a more complex distribution of dipoles and that single dipole fits may be more predictive of typical BREC than multiple dipole fits. The implications of these results are discussed.
临床文献表明，虽然儿童良性罗兰多癫痫（BREC）的临床特征和表现已为人所知，但其癫痫病灶的神经元机制却知之甚少。临床亚型的分类通常是通过确定是否存在脑损伤的补充临床体征来进行的，在这种情况下，癫痫被归类为非良性或“非典型”。对BREC患者脑电图结果的研究表明，癫痫的起源位于罗兰多裂。我们对24名儿童进行了偶极子源建模研究，比较了单偶极子模型和双偶极子模型的结果。结果表明，非典型BREC患者的偶极子分布更为复杂，与多偶极子拟合相比，单偶极子拟合可能对典型BREC更具预测性。本文讨论了这些结果的意义。
