Torres E M, Williams B R, Tang Y-C, Amon A
Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Cold Spring Harb Symp Quant Biol. 2010;75:445-51. doi: 10.1101/sqb.2010.75.025. Epub 2011 Feb 2.
Aneuploidy refers to karyotypic abnormalities characterized by gain or loss of individual chromosomes. This condition is associated with disease and death in all organisms in which it has been studied. We have characterized the effects of aneuploidy on yeast and primary mouse cells and found it to be detrimental at the cellular level. Furthermore, we find that aneuploid cells exhibit phenotypes consistent with increased energy need and proteotoxic stress. These observations, together with the finding that the additional chromosomes found in aneuploid cells are active, lead us to propose that aneuploidy causes an increased burden on protein synthesis and protein quality-control pathways and so induces an aneuploidy stress response.
非整倍体是指以单个染色体的增加或减少为特征的核型异常。在所有已研究的生物体中，这种情况都与疾病和死亡有关。我们已经描述了非整倍体对酵母和原代小鼠细胞的影响，并发现它在细胞水平上是有害的。此外，我们发现非整倍体细胞表现出与能量需求增加和蛋白质毒性应激相一致的表型。这些观察结果，连同在非整倍体细胞中发现的额外染色体是活跃的这一发现，使我们提出非整倍体会导致蛋白质合成和蛋白质质量控制途径的负担增加，从而诱导非整倍体应激反应。
