Torres Eduardo M, Williams Bret R, Amon Angelika
David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Genetics. 2008 Jun;179(2):737-46. doi: 10.1534/genetics.108.090878.
A change in chromosome number that is not the exact multiple of the haploid karyotype is known as aneuploidy. This condition interferes with growth and development of an organism and is a common characteristic of solid tumors. Here, we review the history of studies on aneuploidy and summarize some of its major characteristics. We will then discuss the molecular basis for the defects caused by aneuploidy and end with speculations as to whether and how aneuploidy, despite its deleterious effects on organismal and cellular fitness, contributes to tumorigenesis.
染色体数目变化若不是单倍体核型的精确倍数，则被称为非整倍体。这种情况会干扰生物体的生长和发育，是实体瘤的一个常见特征。在此，我们回顾非整倍体的研究历史，并总结其一些主要特征。然后，我们将讨论非整倍体导致缺陷的分子基础，最后推测尽管非整倍体对生物体和细胞适应性有有害影响，但它是否以及如何促进肿瘤发生。
