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前列腺素抑制剂:痛经的合理治疗方法。

Prostaglandin inhibitors: rational therapy for dysmenorrhea.

出版信息

Can Fam Physician. 1982 Jan;28:91-4.

PMID:21289848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2306303/
Abstract

Dysmenorrhea affects at least 50% of women at some time in their lives. Painful contractions of the uterine muscle (similar to labor pains) are triggered by increased endometrial synthesis of prostaglandins, which appear in elevated amounts in the plasma and menstrual fluid of women with dysmenorrhea. Non-steroidal anti-inflammatory drugs, which have been used for years in arthritis, are effective prostaglandin inhibitors. Taken by mouth at the onset of menstruation, they can relieve dysmenorrhea in the majority of cases. This is a major advantage for women in whom oral contraceptives are not indicated.

摘要

痛经至少影响 50%的女性在其一生中的某个时间。疼痛的子宫肌肉收缩(类似于分娩疼痛)是由增加的前列腺素在内膜合成引发的,在痛经妇女的血浆和月经液中含量升高。非甾体抗炎药,多年来一直用于关节炎,是有效的前列腺素抑制剂。在月经开始时口服,它们可以缓解大多数情况下的痛经。对于不适合口服避孕药的女性来说,这是一个主要的优势。

相似文献

1
Prostaglandin inhibitors: rational therapy for dysmenorrhea.前列腺素抑制剂:痛经的合理治疗方法。
Can Fam Physician. 1982 Jan;28:91-4.
2
Nonsteroidal anti-inflammatory drugs and changing attitudes toward dysmenorrhea.非甾体抗炎药与对痛经态度的转变
Am J Med. 1988 May 20;84(5A):23-9. doi: 10.1016/0002-9343(88)90473-1.
3
Dysmenorrhoea and prostaglandins: pharmacological and therapeutic considerations.痛经与前列腺素:药理学及治疗学考量
Drugs. 1981 Jul;22(1):42-56. doi: 10.2165/00003495-198122010-00003.
4
[Dysmenorrhea induced by lumbosacral spine disorders. Pathogenesis, diagnosis and therapy with special emphasis on spinal manipulative therapy].[腰骶椎疾病所致痛经。发病机制、诊断及治疗,特别强调脊柱推拿疗法]
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Dysmenorrhea.痛经
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Dysfunctional uterine bleeding and dysmenorrhea.功能失调性子宫出血和痛经。
Eur J Contracept Reprod Health Care. 1997 Dec;2(4):229-37. doi: 10.3109/13625189709165299.
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Prostaglandins in primary dysmenorrhea. Comparison of prophylactic and nonprophylactic treatment with ibuprofen and use of oral contraceptives.原发性痛经中的前列腺素。布洛芬预防性和非预防性治疗及口服避孕药使用的比较。
Am J Med. 1981 Mar;70(3):535-41. doi: 10.1016/0002-9343(81)90576-3.
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New concepts in dysmenorrhea.痛经的新概念。
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9
Plasma concentrations of vasopressin and a prostaglandin F2 alpha metabolite in women with primary dysmenorrhoea before and during treatment with a combined oral contraceptive.原发性痛经女性在服用复方口服避孕药治疗前及治疗期间血管加压素和前列腺素F2α代谢物的血浆浓度。
J Endocrinol. 1987 Nov;115(2):355-61. doi: 10.1677/joe.0.1150355.
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Modern treatment of dysmenorrhea.痛经的现代治疗方法。
Acta Obstet Gynecol Scand. 1990;69(7-8):563-4. doi: 10.3109/00016349009028696.

本文引用的文献

1
Phenylbutazone in the treatment of dysmenorrhoea.保泰松治疗痛经。
Practitioner. 1960 Jun;184:787-9.
2
PROSTAGLANDINS IN ENDOMETRIUM AND MENSTRUAL FLUID FROM NORMAL AND DYSMENORRHOEIC SUBJECTS.正常及痛经患者子宫内膜和月经液中的前列腺素
J Obstet Gynaecol Br Commonw. 1965 Apr;72:185-92. doi: 10.1111/j.1471-0528.1965.tb01415.x.
3
The treatment of dysmenorrhoea with phenylbutazone.用保泰松治疗痛经。
Can Med Assoc J. 1958 Nov 1;79(9):752-3.
4
A plain-muscle stimulant in the menstruum.一种月经期间的平滑肌兴奋剂。
Nature. 1957 Nov 30;180(4596):1198-9. doi: 10.1038/1801198a0.
5
Oral contraceptives and cardiovascular disease (first of two parts).口服避孕药与心血管疾病(两部分中的第一部分)
N Engl J Med. 1981 Sep 10;305(11):612-8. doi: 10.1056/NEJM198109103051104.
6
Prostaglandins in primary dysmenorrhea. Comparison of prophylactic and nonprophylactic treatment with ibuprofen and use of oral contraceptives.原发性痛经中的前列腺素。布洛芬预防性和非预防性治疗及口服避孕药使用的比较。
Am J Med. 1981 Mar;70(3):535-41. doi: 10.1016/0002-9343(81)90576-3.
7
Primary dysmenorrhea: the therapeutic challenge.原发性痛经:治疗挑战
J Reprod Med. 1980 Oct;25(4 Suppl):226-35.
8
A rationale for the treatment of dysmenorrhea.痛经的治疗原理。
J Reprod Med. 1980 Oct;25(4 Suppl):213-21.
9
Severe, primary dysmenorrhea treated with naproxen. A prospective, double-blind, crossover investigation.萘普生治疗重度原发性痛经。一项前瞻性、双盲、交叉研究。
Prostaglandins. 1980 May;19(5):651-7. doi: 10.1016/0090-6980(80)90164-1.
10
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.