Hamann G O
Prostaglandins. 1980 May;19(5):651-7. doi: 10.1016/0090-6980(80)90164-1.
26 women aged 15-45 with severe, primary dysmenorrhea were treated with naproxen (NAPROSYN, SYNTEX) and placebo during 2 x 2 consecutive menstrual cycles in a randomized, double-blind crossover study. The dosage of naproxen was 500 mg (2 tablets) initially, followed by 250 mg as needed, with a maximum of 1250 mg daily. In most cases medication started at the first sign of menstrual distress. 80 per cent of the women preferred naproxen to placebo. The number of tablets taken during each menstruation fell from a mean of 17.8 in the placebo period to 5.1 in the naproxen period. Likewise, additional analgesics fell from 7.1 to 1.6 and hours of bed rest from 16.4 to 1.2. Total number of days of sick leave per two menstruations decreased from 40 to 7. These differences are statistically significant (P < 0.001). The side effects were mild. CNS or gastrointestinal side effects were not seen. Naproxen changed the amount of bleeding in 12 and delayed bleeding in three. Two developed acne, which however gradually diminished during the next five bleeding periods treated with naproxen. The influence of prostaglandin synthetase inhibitors on the ovarian production of steroids is discussed.
在一项随机、双盲交叉研究中，26名年龄在15至45岁之间患有严重原发性痛经的女性，在连续两个月经周期中接受了萘普生（萘普生片，先灵葆雅公司生产）和安慰剂治疗。萘普生的剂量起初为500毫克（2片），随后按需服用250毫克，每日最大剂量为1250毫克。在大多数情况下，药物在月经疼痛的最初迹象出现时开始服用。80%的女性更喜欢萘普生而非安慰剂。每个月经周期服用的药片数量从安慰剂期的平均17.8片降至萘普生期的5.1片。同样，额外使用的镇痛药从7.1次降至1.6次，卧床休息时间从16.4小时降至1.2小时。每两个月经周期的病假总天数从40天降至7天。这些差异具有统计学意义（P < 0.001）。副作用较轻。未观察到中枢神经系统或胃肠道副作用。萘普生使12名女性的出血量发生变化，3名女性的出血时间延迟。两名女性出现痤疮，但在接下来用萘普生治疗的五个出血周期中逐渐减轻。文中讨论了前列腺素合成酶抑制剂对卵巢甾体激素产生的影响。
