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自组装蔷薇状纳米管用于在生理环境中包载疏水性药物。

Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments.

机构信息

School of Engineering, Brown University, Providence, RI 02912, USA.

出版信息

Int J Nanomedicine. 2011 Jan 10;6:101-7. doi: 10.2147/IJN.S11957.

DOI:10.2147/IJN.S11957
PMID:21289987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3026575/
Abstract

Rosette nanotubes (RNTs) are novel, biomimetic, injectable, self-assembled nanomaterials. In previous studies, materials coated with RNTs have significantly increased cell growth (eg, osteoblasts, chondrocytes, and endothelial cells) due to the favorable cellular environment created by RNTs. It has also been suggested that the tubular RNT structures formed by base stacking and hydrophobic interactions can be used for drug delivery, and this possibility has not been studied to date. Here we investigated methods to load and deliver tamoxifen (TAM, a hydrophobic anticancer drug) using two different types of RNTs: single- base RNTs and twin-base RNTs. Drug-loaded RNTs were characterized by nuclear magnetic resonance spectroscopy, diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY NMR), and ultraviolet-visible (UV-Vis) spectroscopy at different ratios of twin-base RNTs to TAM. The results demonstrated successful incorporation of hydrophobic TAM into RNTs. Importantly, because of the hydrophilicity of the outer surface of the RNTs, TAM-loaded RNTs were dissolved in water, and thus have great potential to deliver hydrophobic drugs in various physiological environments. The results also showed that twin-base RNTs further improved TAM loading. Therefore, this study demonstrated that hydrophobic pharmaceutical agents (such as TAM), once considered hard to deliver, can be easily incorporated into RNTs for anticancer treatment purposes.

摘要

罗氏纳米管（RNTs）是一种新型的仿生、可注射、自组装纳米材料。在以前的研究中，由于 RNTs 创造了有利的细胞环境，涂覆有 RNTs 的材料显著增加了细胞的生长（例如成骨细胞、软骨细胞和内皮细胞）。也有人提出，由碱基堆积和疏水相互作用形成的管状 RNT 结构可用于药物输送，迄今为止尚未对此可能性进行研究。在这里，我们研究了使用两种不同类型的 RNTs（单碱基 RNTs 和双碱基 RNTs）加载和输送他莫昔芬（TAM，一种疏水抗癌药物）的方法。通过核磁共振波谱、扩散排序核磁共振波谱（DOSY NMR）和不同比例的双碱基 RNTs 与 TAM 的紫外可见（UV-Vis）光谱对载药 RNTs 进行了表征。结果表明成功地将疏水性 TAM 掺入 RNTs 中。重要的是，由于 RNTs 外表面的亲水性，载有 TAM 的 RNTs 可溶于水，因此在各种生理环境下输送疏水性药物具有很大的潜力。结果还表明，双碱基 RNTs 进一步提高了 TAM 的载药量。因此，本研究表明，曾经被认为难以输送的疏水性药物制剂（如 TAM）可以很容易地掺入 RNTs 中，用于抗癌治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/cb00b99551c7/ijn-6-101f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/cf67b846e010/ijn-6-101f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/2ddb6e9c8336/ijn-6-101f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/f537cb70bc2d/ijn-6-101f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/d14d690dad35/ijn-6-101f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/338b6b229b4e/ijn-6-101f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/cb00b99551c7/ijn-6-101f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/cf67b846e010/ijn-6-101f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/2ddb6e9c8336/ijn-6-101f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/f537cb70bc2d/ijn-6-101f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/d14d690dad35/ijn-6-101f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/338b6b229b4e/ijn-6-101f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb50/3026575/cb00b99551c7/ijn-6-101f6.jpg

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