TRPC2：只见于鼠，不见于人。

TRPC2: of mice but not men.

机构信息

Department of Biosciences, Åbo Akademi University, 20520 Turku, Finland.

出版信息

Adv Exp Med Biol. 2011;704:125-34. doi: 10.1007/978-94-007-0265-3_6.

Abstract

Relatively little is known in regard to the physiological significance of TRPC2 and its regulation or interaction with other calcium regulating signalling molecules. In rodents, however, the importance of TRPC2 is indisputable. In mice, transcripts for TRPC2 have been found in testis, sperm, in neurons in the vomeronasal organ, and both in the dorsal root ganglion and in the brain. In rats, TRPC2 is thought to be expressed exclusively in the vomeronasal organ. In mice, TRPC2 is of importance in regulating both sexual and social behaviour. In sperm, TRPC2 is of importance in the acrosome reaction. This review will summarize the known physiological effects of TRPC2 channels, and the regulation of the function of the channel. In addition, some new preliminary data on the role of TRPC2 in rat thyroid cells will be presented.

摘要

关于 TRPC2 的生理意义及其与其他钙调节信号分子的调节或相互作用，人们知之甚少。然而，在啮齿动物中，TRPC2 的重要性是无可争议的。在小鼠中，TRPC2 的转录本已在睾丸、精子、犁鼻器神经元以及背根神经节和大脑中被发现。在大鼠中，TRPC2 被认为仅在犁鼻器中表达。在小鼠中，TRPC2 在调节性行为和社交行为方面都很重要。在精子中，TRPC2 对顶体反应很重要。本文将总结 TRPC2 通道的已知生理作用及其功能的调节。此外，还将介绍一些关于 TRPC2 在大鼠甲状腺细胞中作用的新初步数据。