Facultad de Ciencias, Centro Interdisciplinario de Neurociencias de Valparaíso Universidad de Valparaíso, Valparaíso, Chile.
Adv Exp Med Biol. 2011;704:469-90. doi: 10.1007/978-94-007-0265-3_26.
In this chapter we discuss the polymodal activation of thermo-TRP channels using as exemplars two of the best characterized members of this class of channels: TRPM8 and TRPV1. Since channel activation by temperature is the hallmark of thermo-TRP channels, we present a detailed discussion on the thermodynamics involved in the gating processes by temperature, voltage, and agonists. We also review recently published data in an effort to put together all the pieces available of the amazing puzzle of thermo-TRP channel activation. Special emphasis is made in the structural components that allow the channel-forming proteins to integrate such diverse stimuli, and in the coupling between the different sensors and the ion conduction pathway. We conclude that the present data is most economically explained by allosteric models in which temperature, voltage, and agonists act separately to modulate channel activity.
在本章中，我们将讨论使用热 TRP 通道的多模式激活，以这一类通道中两个研究得最好的成员为例：TRPM8 和 TRPV1。由于温度对通道的激活是热 TRP 通道的标志，我们将详细讨论温度、电压和激动剂门控过程中的热力学。我们还回顾了最近发表的数据，努力将热 TRP 通道激活这一惊人谜题的所有可用部分放在一起。特别强调了允许通道形成蛋白整合如此多样刺激的结构成分，以及不同传感器和离子传导途径之间的耦合。我们得出的结论是，目前的数据最合理的解释是变构模型，其中温度、电压和激动剂分别作用于调节通道活性。
