Departamento de Neurodesarrollo y Fisiología, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, D.F., 04510, Mexico.
Curr Top Med Chem. 2011;11(17):2131-50. doi: 10.2174/156802611796904870.
Transient Receptor Potential (TRP) cation channels participate in several processes of vital importance in cell and organism physiology, and have been demonstrated to participate in the detection of sensory stimuli. The thermo TRP's reviewed: TRPV1 (vanilloid 1), TRPM8 (melastatin 8) and TRPA1 (ankyrin-like 1) are known to integrate different chemical and physical stimuli such as changes in temperature and sensing different irritant or pungent compounds. However, despite the physiological importance of these channels the mechanisms by which they detect incoming stimuli, how the sensing domains are coupled to channel gating and how these processes are connected to specific structural regions in the channel are not fully understood, but valuable information is available. Many sites involved in agonist detection have been characterized and gating models that describe many features of the channel's behavior have been put forward. In this review we will survey some of the key findings concerning the structural and molecular mechanisms of TRPV1, TRPA1 and TRPM8 activation.
瞬时受体电位 (TRP) 阳离子通道参与细胞和机体生理学中几个非常重要的过程，并已被证明参与了对感觉刺激的检测。本文综述了几种热敏 TRP 通道：TRPV1（香草素 1）、TRPM8（melastatin 8）和 TRPA1（ankyrin-like 1），它们被认为整合了不同的化学和物理刺激，如温度变化和感知不同的刺激性或刺激性化合物。然而，尽管这些通道具有重要的生理意义，但它们检测传入刺激的机制、感应结构域与通道门控的耦联方式以及这些过程与通道中特定结构区域的连接方式尚不完全清楚，但已经有了有价值的信息。已经对许多涉及激动剂检测的部位进行了表征，并提出了描述通道行为许多特征的门控模型。在这篇综述中，我们将调查有关 TRPV1、TRPA1 和 TRPM8 激活的结构和分子机制的一些关键发现。
