丹卡林 A 的不对称全合成及生物活性评价。
Asymmetric total synthesis of danicalipin A and evaluation of biological activity.
机构信息
Division of Environmental Materials Science, Graduate School of Environmental Science, Hokkaido University, Sapporo, Japan.
出版信息
Org Lett. 2011 Mar 4;13(5):904-7. doi: 10.1021/ol102882a. Epub 2011 Feb 3.
PMID:21291262
Abstract
Asymmetric total synthesis of danicalipin A was achieved. The synthesis was characterized by diastereoselective introduction of chlorine atoms. Biological activities with synthetic danicalipin A, its enantiomer, and racemate were also evaluated toward brine shrimp. Both enantiomers of danicalipin A showed almost the same activity.
摘要
达卡脂素 A 的非对映选择性全合成研究。该合成的特点是氯原子的非对映选择性引入。还评估了合成的达卡脂素 A 及其对映异构体和外消旋体对卤虫的生物活性。达卡脂素 A 的两种对映异构体表现出几乎相同的活性。
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