University of Zurich, Zurich, Switzerland.
Emerg Infect Dis. 2011 Feb;17(2):180-5. doi: 10.3201/eid1702.100909.
We characterized 97 non-O157 Shiga toxin (stx)-producing Escherichia coli strains isolated from human patients during 2000-2009 from the national reference laboratory in Switzerland. These strains belonged to 40 O:H serotypes; 4 serotypes (O26:H11/H-, O103:H2, O121:H19, and O145:H28/H-) accounted for 46.4% of the strains. Nonbloody diarrhea was reported by 23.2% of the patients, bloody diarrhea by 56.8%. Hemolytic uremic syndrome developed in 40.0% of patients; serotype O26:H11/H- was most often associated with this syndrome. Forty-five (46.4%) strains carried stx2 genes only, 36 strains (37.1%) carried stx1, and 16 (16.5%) strains carried stx1 and stx2. Genes encoding enterohemolysin and intimin were detected in 75.3% and 70.1% of the strains, respectively. Resistance to ≥1 antimicrobial agent was present in 25 isolates. High genetic diversity within strains indicates that non-O157 stx-producing E. coli infections in Switzerland most often occurred as single cases.
我们从瑞士国家参考实验室鉴定了 2000 年至 2009 年期间从人类患者中分离出的 97 株非 O157 志贺毒素（stx）产生大肠杆菌。这些菌株属于 40 个 O:H 血清型；4 个血清型（O26：H11/H-、O103：H2、O121：H19 和 O145：H28/H-）占菌株的 46.4%。23.2%的患者报告有非血性腹泻，56.8%的患者有血性腹泻。40.0%的患者发生溶血性尿毒综合征；血清型 O26：H11/H- 与该综合征最相关。45 株（46.4%）菌株仅携带 stx2 基因，36 株（37.1%）菌株携带 stx1，16 株（16.5%）菌株携带 stx1 和 stx2。75.3%和 70.1%的菌株分别携带编码肠出血素和侵袭素的基因。25 株对至少 1 种抗菌药物具有耐药性。菌株内的高遗传多样性表明，瑞士的非 O157 产志贺毒素大肠杆菌感染大多为单一病例。
