Rao A J, Chakraborti R, Kotagi S G, Ravindranath N
Center for Reproductive Biology and Molecular Endocrinology, Indian Institute of Science, Bangalore.
Andrologia. 1990 Nov-Dec;22(6):567-73. doi: 10.1111/j.1439-0272.1990.tb02056.x.
The effect of chronic infusion of gonadotropic hormone agonist Buserelin or antagonist CDB 2085 A for 15 weeks via alzet minipumps in adult male bonnet monkeys was studied. Infusion of Buserelin resulted in a decrease in the difference between serum testosterone values at 22.00 hours and 10.00 hours, decrease in responsiveness to injected Buserelin as judged by change in serum testosterone values from pre-injection values and decrease in sperm counts. Infusion of antagonist resulted in a decrease in the difference between serum testosterone values at 22.00 hours and 10.00 hours.
研究了通过阿尔泽微型泵对成年雄性冠毛猕猴连续15周输注促性腺激素激动剂布舍瑞林或拮抗剂CDB 2085 A的效果。输注布舍瑞林导致22:00时和10:00时血清睾酮值之间的差异减小，根据血清睾酮值相对于注射前值的变化判断，对注射布舍瑞林的反应性降低，精子计数减少。输注拮抗剂导致22:00时和10:00时血清睾酮值之间的差异减小。
