Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
Neurosci Lett. 2011 Apr 1;492(2):109-13. doi: 10.1016/j.neulet.2011.01.067. Epub 2011 Feb 1.
Recently, neural substrates of the Big Five personality model were investigated using neuroimaging. We examined the relationships between the amplitude of spontaneous low-frequency oscillations (LFO) and the Big Five traits using resting-state functional magnetic resonance imaging (R-fMRI). Twenty-four healthy right-handed undergraduates (23.13±1.87 years, 9 males and 15 females) participated in 5-min R-fMRI and completed the NEO Five-Factor Inventory. We observed that Neuroticism correlated negatively with regional activity of the middle frontal gyrus and precuneus; Extraversion correlated positively with regional activity of the striatum, precuneus, and superior frontal gyrus; Openness correlated positively with the thalamus and amygdala, and negatively with the superior frontal gyrus; Conscientiousness correlated positively with regional activity of the middle frontal gyrus and correlated negatively with the cerebellum. Our results revealed the neural substrates of Extraversion, Neuroticism, Openness, and Conscientiousness in the amplitude of spontaneous LFO.
最近，使用神经影像学研究了大五人格模型的神经基础。我们使用静息态功能磁共振成像（R-fMRI）检查了自发低频振荡（LFO）幅度与大五人格特质之间的关系。24 名健康右利手大学生（23.13±1.87 岁，9 名男性和 15 名女性）参加了 5 分钟的 R-fMRI 扫描，并完成了 NEO 五因素人格问卷。我们观察到神经质与额中回和楔前叶的局部活动呈负相关；外向性与纹状体、楔前叶和额上回的局部活动呈正相关；开放性与丘脑和杏仁核呈正相关，与额上回呈负相关；尽责性与额中回的局部活动呈正相关，与小脑呈负相关。我们的结果揭示了大五人格模型中外向性、神经质、开放性和尽责性的自发 LFO 幅度的神经基础。
