Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Hum Brain Mapp. 2014 Jan;35(1):331-9. doi: 10.1002/hbm.22176. Epub 2012 Sep 15.
The biological model of extraversion and neuroticism identified by Eysenck has stimulated increasing interest in uncovering neurobiological substrate of the two fundamental dimensions. Here we aim to explore brain disturbances underlying extraversion and neuroticism in 87 healthy individuals using fractional amplitude of low-frequency fluctuations (LFF) on resting-state functional magnetic resonance imaging. Two different frequency bands, Slow-5 (0.01-0.027 Hz) exhibiting higher power and involving larger brain regions, and Slow-4 (0.027-0.073 Hz) exhibiting less power and emerging locally, were analyzed. Our results showed a positive correlation between LFF amplitude at Slow-5 and extraversion in medial prefrontal cortex and precuneus, important portions of the default mode network, thus suggesting a link between default network activity and personality traits. LFF amplitude at Slow-5 was correlated positively with neuroticism in right posterior portion of the frontal lobe, further validating neuroticism with frontal lateralization. In addition, LFF amplitude at Slow-4 was negatively associated with extraversion and neuroticism in left hippocampus (HIP) and bilateral superior temporal cortex (STC) respectively, supporting the hypothesized (inverse) relationship between extraversion and resting arousal, also implying neural circuit underlying emotional process influencing on personality. Overall, these findings suggest the important relationships, between personality and LFF amplitude dynamic, depend on specific frequency bands.
艾森克提出的外向性和神经质的生物学模型激发了人们越来越大的兴趣，去揭示这两个基本维度的神经生物学基础。在这里，我们旨在使用静息态功能磁共振成像的低频振幅分数（LFF），探索 87 名健康个体的外向性和神经质的大脑紊乱。我们分析了两个不同的频带，Slow-5（0.01-0.027 Hz）具有较高的功率，涉及更大的脑区，Slow-4（0.027-0.073 Hz）的功率较低，且在局部出现。我们的结果显示，Slow-5 的 LFF 振幅与内侧前额叶皮质和楔前叶的外向性呈正相关，默认模式网络的重要组成部分，这表明默认网络活动与人格特质之间存在联系。Slow-5 的 LFF 振幅与右侧额叶后部的神经质呈正相关，进一步验证了额叶外侧化的神经质。此外，Slow-4 的 LFF 振幅与左侧海马体（HIP）和双侧颞上回（STC）的外向性和神经质呈负相关，分别支持外向性和静息唤醒之间的假设（反向）关系，这也暗示了影响人格的情绪过程的神经回路。总的来说，这些发现表明，人格与 LFF 振幅动态之间的重要关系取决于特定的频带。
