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主动升主动脉修复的二叶式主动脉瓣手术。

Bicuspid aortic valve surgery with proactive ascending aorta repair.

机构信息

Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

出版信息

J Thorac Cardiovasc Surg. 2011 Sep;142(3):622-9, 629.e1-3. doi: 10.1016/j.jtcvs.2010.10.050. Epub 2011 Feb 3.

Abstract

OBJECTIVES

Bicuspid aortic valves are associated with aortic catastrophes, particularly dissection. We examined whether proactive repair of associated dilatation would reduce risk of subsequent aortic dissection or reoperation and whether more aggressive resection is needed in patients undergoing bicuspid aortic valve surgery alone.

METHODS

From January 1993 to June 2003, 1989 patients (of our total experience of 4316) underwent bicuspid aortic valve surgery. Long-term outcomes of 1810 were analyzed according to aortic size and whether bicuspid aortic valve surgery was performed alone or with aortic repair.

RESULTS

In-hospital 30-day survival was similar (98.8% valve alone vs 98.9% with aortic repair), with no penalty incurred for concomitant aortic repair. Bicuspid aortic valve-alone patients had worse late survival (75% vs 85% at 10 years, P = .0001), but in the matched cohort survival was nearly identical (85% vs 86%; P = .7). With this strategy, freedom from late aortic events was high in both groups (99% valve alone vs 97% with aortic repair at 10 years; P[log-rank] = .06) and similar in the matched cohort (95% vs 97%; P = .2). Approximately 95% of patients undergoing valve-alone surgery had aortic diameters smaller than 4.6 cm or cross-sectional area/height ratios less than 9.4 cm(2)/m; 80% undergoing valve surgery plus aortic repair had diameters larger than 4.1 cm or ratios greater than 7.3 cm(2)/m. Only 0.2% of events occurred at an aortic diameter size of less than 4.5 cm.

CONCLUSIONS

Aortic size larger than 4.5 cm or aortic cross-sectional area/height ratio greater than 8 to 10 should be considered triggers for concurrent aortic repair, because there is no added risk, and late survival is better; however, more aggressive resection is unwarranted.

摘要

目的

二叶式主动脉瓣与主动脉灾难有关,特别是夹层。我们研究了积极修复相关扩张是否会降低随后发生主动脉夹层或再次手术的风险,以及在单独进行二叶式主动脉瓣手术的患者中是否需要更激进的切除。

方法

1993 年 1 月至 2003 年 6 月,我们对 1989 名患者(我们 4316 例手术的总经验)进行了二叶式主动脉瓣手术。根据主动脉大小以及是否单独进行二叶式主动脉瓣手术或同时进行主动脉修复,分析了 1810 名患者的长期结果。

结果

住院 30 天的生存率相似(单独行瓣手术组为 98.8%,同时行瓣手术和主动脉修复组为 98.9%),同时行主动脉修复未导致死亡率增加。单独行瓣手术组的晚期生存率较差(10 年时为 75%,而同期为 85%,P =.0001),但在匹配队列中两组的生存率几乎相同(85%比 86%;P =.7)。采用这种策略,两组的晚期主动脉事件无事件生存率均较高(单独行瓣手术组 10 年时为 99%,同期为 97%;P[log-rank] =.06),在匹配队列中也相似(95%比 97%;P =.2)。大约 95%的单独行瓣手术患者的主动脉直径小于 4.6 厘米或截面积/身高比小于 9.4 cm(2)/m;80%行瓣手术加主动脉修复的患者的直径大于 4.1 厘米或比值大于 7.3 cm(2)/m。只有 0.2%的事件发生在主动脉直径小于 4.5 厘米。

结论

主动脉直径大于 4.5 厘米或主动脉截面积/身高比大于 8 到 10 应被视为同时行主动脉修复的触发因素,因为这样做没有增加风险,且晚期生存率更好;然而,更激进的切除是不必要的。

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