Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, Medical University of Warsaw, ul Banacha 1, 02-097 Warsaw, Poland.
Eur J Med Chem. 2011 Mar;46(3):914-8. doi: 10.1016/j.ejmech.2011.01.006. Epub 2011 Jan 18.
The controlled release of 5-fluorouracil (5FU) from aliphatic poly(amide urethane)s (PURs) was studied in vitro. Linear PUR conjugates were prepared by the reaction between oligo(ɛ-caprolactone) (PCL), oligolactide (PLA), copolymers of ɛ-caprolactone (CL) and rac-lactide (rac-LA), dihydroxy(polyethylene adipate) (OEDA) with 1,6-diisocyanatohexane (HDI). Release of 5FU from PURs was found to depend on the nature of oligoester units and consist of soft and hard segments.
聚（酰胺-氨酯）（PURs）中 5-氟尿嘧啶（5FU）的控制释放在体外进行了研究。通过己内酯（PCL）、低聚丙交酯（PLA）、ε-己内酯（CL）和丙交酯（rac-LA）共聚物、二羟基亚己酸（OEDA）与 1,6-己二异氰酸酯（HDI）之间的反应制备了线性 PUR 共轭物。发现 5FU 从 PURs 中的释放取决于低聚物单元的性质，并由软段和硬段组成。
