Żółtowska Karolina, Piotrowska Urszula, Oledzka Ewa, Kuras Marzena, Zgadzaj Anna, Sobczak Marcin
Department of Biomaterials Chemistry, Chair of Inorganic and Analytical Chemistry, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha St., Warsaw, 02-097, Poland.
Department of Environmental Health Science, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha St., Warsaw, 02-097, Poland.
Pharm Res. 2017 Apr;34(4):780-792. doi: 10.1007/s11095-017-2105-7. Epub 2017 Jan 24.
The purpose of this study was to develop the perspective biodegradable poly(ester-urethane) (PUR) carriers based on "predominantly isotactic" and atactic polylactides (PLAs), and poly(ε-caprolactone) (PCL), for the controlled release of epirubicin (EPI).
The biodegradable PURs containing different soft segments as new and effective carriers of EPI have been obtained. The preliminary studies on toxicity and degradation of obtained polymers, and the release of the EPI from PUR carriers were carried out.
We found that the kinetic release of EPI from the obtained PUR carriers tested in vitro at 37°C and pH 7.4 was strongly dependent on the kind of the polyesters, used as the soft segment in PURs synthesis. Furthermore, we demonstrated that the EPI was released from various synthesized carriers in a rather regular manner, according to the diffusion-degradation and degradation mechanisms. Importantly, in some cases, the kinetics of the EPI release was nearly zero-order.
The results show that the obtained PURs are very effective and perspective carriers and might be potentially applied in the technology of high controlled EPI delivery systems.
本研究的目的是开发基于“主要全同立构”和无规聚乳酸（PLA）以及聚（ε-己内酯）（PCL）的可降解聚（酯-聚氨酯）（PUR）载体，用于表柔比星（EPI）的控释。
已获得含有不同软段的可降解PUR，作为EPI的新型有效载体。对所得聚合物的毒性和降解以及EPI从PUR载体中的释放进行了初步研究。
我们发现，在37°C和pH 7.4条件下体外测试时，EPI从所得PUR载体中的动力学释放强烈依赖于用作PUR合成软段的聚酯种类。此外，我们证明EPI根据扩散-降解和降解机制以相当规则的方式从各种合成载体中释放。重要的是，在某些情况下，EPI释放动力学几乎是零级的。
结果表明，所得PUR是非常有效的和有前景的载体，可能潜在地应用于高控释EPI递送系统技术中。
