Tabita K, Sakaguchi S, Kozaki S, Sakaguchi G
Osaka Prefectural Institute of Public Health.
Jpn J Med Sci Biol. 1990 Dec;43(6):219-31. doi: 10.7883/yoken1952.43.219.
Twenty strains of Clostridium botulinum type A associated with infant botulism cases, six in Japan and 14 in California, USA, were compared in their characters. All six Japanese strains produced medium-sized progenitor toxin (M toxin; Mr 300 k) but no hemagglutinin and showed lower 50% infective doses (ID50) in the infant mouse test; whereas most American strains produced large-sized progenitor toxin (L + LL toxins; Mr 500 k and 900 k) and hemagglutinin in addition to M toxin and showed higher ID50 in infant mice. No marked difference in the biochemical properties was found between the two groups except for two American strains.
对与婴儿肉毒中毒病例相关的20株A型肉毒梭菌进行了特性比较，其中6株来自日本，14株来自美国加利福尼亚州。所有6株日本菌株都产生中等大小的前体毒素（M毒素；分子量300k），但不产生血凝素，并且在幼鼠试验中显示出较低的50%感染剂量（ID50）；而大多数美国菌株除了产生M毒素外，还产生大尺寸的前体毒素（L + LL毒素；分子量500k和900k）和血凝素，并且在幼鼠中显示出较高的ID50。除了两株美国菌株外，两组之间在生化特性上没有发现明显差异。
