家庭医学中心中苯二氮䓬类药物使用模式。
Patterns of benzodiazepine usage in a family medicine centre.
出版信息
Can Fam Physician. 1980 May;26:718-20.
In a one year survey of the use of diazepam, chlordiazepoxide and flurazepam at a university family medicine centre, the per capita prescribing of the three drugs rose with the age of the patients. Diazepam was used approximately four times as frequently as chlordiazepoxide and for four times as many problems, even though it has similar pharmacological properties and a half-life nearly three times that of chlordiazepoxide. The over 65 age group received 36% of prescriptions for diazepam for more than six months, compared to three percent in the under 65 age group. Use of lower doses of shorter acting benzodiazepines in the over 65 age group, for a shorter duration, seems to be more rational than patterns determined in the study. A follow up study to measure the impact of the findings on the physicians' prescribing patterns is planned.
在对一所大学附属医院的苯二氮䓬类药物（地西泮、氯氮䓬和氟西泮）的使用情况进行的为期一年的调查中，三种药物的人均处方量随患者年龄的增长而增加。地西泮的使用频率约为氯氮䓬的四倍，出现的问题也约为氯氮䓬的四倍，尽管两者具有相似的药理学特性，且地西泮的半衰期几乎是氯氮䓬的三倍。65 岁以上年龄组开具地西泮超过六个月的处方占 36%，而 65 岁以下年龄组的这一比例为 3%。在 65 岁以上年龄组中使用较低剂量、作用时间较短的苯二氮䓬类药物，且使用时间较短，这种治疗方案似乎比研究中确定的方案更合理。计划进行一项后续研究，以衡量这些发现对医生处方模式的影响。
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