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发展中国家婴儿猝死综合征的流行病学特征及诊断策略。

Epidemiological profile and strategies for diagnosing SIDS in a developing country.

机构信息

Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.

出版信息

J Pediatr (Rio J). 2011 Mar-Apr;87(2):115-22. doi: 10.2223/JPED.2068. Epub 2011 Feb 3.

DOI:10.2223/JPED.2068
PMID:21293832
Abstract

OBJECTIVE

To describe the epidemiological profile, risk factors and best strategies for diagnosing sudden infant death syndrome (SIDS) in a developing country.

METHODS

Population-based, case-control study with children born between January 1st, 2001, and December 31st, 2003, in Porto Alegre, southern Brazil, who were allocated into three groups: SIDS cases (33), explained death controls (192), and living controls (192). Children in the latter two groups were age- and sex-paired with SIDS cases. Families in which an infant had died at home within the first year of life were identified, and the information available on death certificates and autopsy reports was compared to confirm the diagnosis of SIDS. Explained death controls consisted of infants who had died at city hospitals, and living controls were selected in the same neighborhood as SIDS cases. All parents were interviewed to obtain information on children's health and sleep habits. Multivariate analysis was performed to identify risk factors in the study population.

RESULTS

The incidence of SIDS in the population assessed was 0.55/1,000 live births. The analysis revealed the following risk factors: ethnicity (characterized by self-reported black skin color), prematurity, low birth weight, adolescent mother, smoking during pregnancy, and family income of less than one minimum wage. Ninety-four percent of SIDS cases were misdiagnosed in the death certificate.

CONCLUSIONS

Although SIDS was misdiagnosed in official death certificates, the epidemiological profile is similar to the literature, as well as risk factors, which could be reduced with preventive campaigns. Investigating SIDS in developing countries requires special strategies to avoid misdiagnosis.

摘要

目的

描述发展中国家婴儿猝死综合征(SIDS)的流行病学特征、危险因素和最佳诊断策略。

方法

本研究为基于人群的病例对照研究,纳入 2001 年 1 月 1 日至 2003 年 12 月 31 日在巴西南部阿雷格里港出生的儿童,分为 SIDS 病例组(33 例)、解释性死亡对照组(192 例)和存活对照组(192 例)。后两组的儿童与 SIDS 病例组在年龄和性别上进行配对。确定在家中死亡的婴儿的家庭,并比较死亡证明和尸检报告中的信息,以确认 SIDS 的诊断。解释性死亡对照组由在市医院死亡的婴儿组成,存活对照组则在 SIDS 病例组所在的同一社区选择。对所有父母进行访谈,以获取儿童健康和睡眠习惯的信息。对研究人群进行多变量分析以确定危险因素。

结果

评估人群中的 SIDS 发病率为 0.55/1000 活产儿。分析显示,以下因素为危险因素:种族(以自我报告的黑色皮肤为特征)、早产、低出生体重、青少年母亲、孕期吸烟以及家庭收入低于最低工资标准。94%的 SIDS 病例在死亡证明中被误诊。

结论

尽管 SIDS 在官方死亡证明中被误诊,但流行病学特征与文献相似,且危险因素可通过预防措施降低。在发展中国家研究 SIDS 需要采取特殊策略来避免误诊。

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