Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, UK.
Arch Virol. 2011 May;156(5):903-6. doi: 10.1007/s00705-011-0922-2. Epub 2011 Feb 4.
Susceptibility of sheep to classical scrapie is determined by polymorphisms in the coding region of the prion protein gene (PRNP), mainly at codons 136, 154 and 171. It has recently been shown that lesion profiles from classical field scrapie isolates that transmitted to RIII mice can be classified into different groups. There was also strong, but not absolute, association between the different groups and codon 136. Here, we examine the hypothesis that additional polymorphisms in the open reading frame sequence of the ovine PRNP may account for the different groups of lesion profiles observed following transmission to mice.
绵羊对经典羊瘙痒病的易感性取决于朊病毒蛋白基因（PRNP）编码区的多态性，主要位于密码子 136、154 和 171。最近已经表明，传播给 RIII 小鼠的经典田间瘙痒病分离株的病变图谱可以分为不同的组。不同的组与密码子 136 之间也存在强烈的关联，但不是绝对的。在这里，我们检验了这样一个假设，即在绵羊 PRNP 的开放阅读框序列中存在额外的多态性，可能解释了在向小鼠传播后观察到的不同病变图谱组。
