通过钯催化的芳基卤化物的酰胺化反应合成酰胺。

Synthesis of amides via palladium-catalyzed amidation of aryl halides.

机构信息

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, P R China.

出版信息

Org Lett. 2011 Mar 4;13(5):1028-31. doi: 10.1021/ol103081y. Epub 2011 Feb 4.

Abstract

A new and efficient method for the synthesis of amides via palladium-catalyzed C-C coupling of aryl halides with isocyanides is reported, by which a series of amides were formed from readily available starting materials under mild conditions. This transformation could extend its use to the synthesis of natural products and significant pharmaceuticals.

摘要

报道了一种通过钯催化芳基卤化物与异氰化物的 C-C 偶联反应合成酰胺的新的、高效的方法，该方法在温和条件下，以易得的起始原料合成了一系列酰胺。这种转化可以扩展到天然产物和重要药物的合成中。