钯催化的由芳基卤化物和二胺合成 2-芳基-2-咪唑啉的多组分反应。
Palladium-catalyzed multicomponent synthesis of 2-aryl-2-imidazolines from aryl halides and diamines.
机构信息
Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
出版信息
J Org Chem. 2013 Apr 19;78(8):4158-64. doi: 10.1021/jo400252n. Epub 2013 Mar 21.
PMID:23472583
Abstract
An efficient palladium-catalyzed three-component reaction that combines aryl halides, isocyanides, and diamines provides access to 2-aryl-2-imidazolines in yields up to 96%. Through variation of the diamine component, the reaction can be extended to the synthesis of 2-aryl-1H-benzimidazoles and 2-aryl-1,4,5,6-tetrahydropyrimidines.
摘要
一种高效的钯催化的三组分反应，可将芳基卤化物、异氰化物和二胺结合在一起，以高达 96%的收率得到 2-芳基-2-咪唑啉。通过改变二胺组分，该反应可扩展到 2-芳基-1H-苯并咪唑和 2-芳基-1,4,5,6-四氢嘧啶的合成。
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