Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120 Heidelberg, Germany.
Hum Pathol. 2011 Jun;42(6):817-23. doi: 10.1016/j.humpath.2010.10.005. Epub 2011 Feb 4.
Solid-pseudopapillary neoplasms of the pancreas are tumors of low malignant potential whose histogenesis has been discussed controversially. In the series of 15 solid-pseudopapillary neoplasms presented here, we demonstrate that discovered on gastrointestinal stromal tumor 1 is expressed significantly by these tumors (diffuse expression in 8 cases, focal expression in 4 cases, and scarce expression in 3 cases). Similar to the high expression of CD117, this finding parallels the immunohistochemical findings in gastrointestinal stromal tumors. Using double immunohistochemistry and immunofluorescence, we furthermore show that centroacinar cells express discovered on gastrointestinal stromal tumors 1. Thus, our findings suggest that, similarly to CD10 or vimentin, the expression of discovered on gastrointestinal stromal tumors 1 may serve as a novel marker for centroacinar cells and for solid-pseudopapillary neoplasms, which is suggestive of a centroacinar origin of these neoplasms.
胰腺实性假乳头状肿瘤是一种低度恶性潜能的肿瘤，其组织发生一直存在争议。在本研究的 15 例胰腺实性假乳头状肿瘤中，我们证实这些肿瘤明显表达胃肠道间质瘤 1（8 例弥漫表达，4 例局灶表达，3 例稀疏表达）。与 CD117 的高表达相似，这一发现与胃肠道间质瘤的免疫组化结果一致。通过双重免疫组化和免疫荧光，我们进一步显示中心腺泡细胞表达胃肠道间质瘤 1。因此，我们的研究结果表明，类似于 CD10 或波形蛋白，胃肠道间质瘤 1 的表达可以作为中心腺泡细胞和胰腺实性假乳头状肿瘤的一个新标志物，提示这些肿瘤可能起源于中心腺泡细胞。
