The Center for Research on Women and Children's Health, The Child Health and Development Studies, Public Health Institute, Berkeley, CA 94709, United States.
Reprod Toxicol. 2011 Apr;31(3):290-6. doi: 10.1016/j.reprotox.2011.01.004. Epub 2011 Feb 3.
Developmental exposure to polychlorinated biphenyls (PCBs) disrupts reproduction in animals. Human data are lacking. We measured PCBs in preserved mothers' serum samples collected during 1960-1963, 1-3 days after their daughters' birth. We recorded time to pregnancy (TTP) in 289 daughters 28-31 years later. PCB congeners 187, 156, and 99 in mother's serum were associated with longer TTP in their daughters while PCB congeners 105, 138 and 183 were associated shorter TTP. Probability of pregnancy fell by 38% (95% CI 17-53%) and infertility was higher (30% not pregnant after 13 cycles versus 11% not pregnant after 13 cycles) among women whose mothers had a higher proportion of PCB congeners associated with longer TTP (75th percentile versus 25th percentile). This study demonstrates, for the first time, that developmental exposure to PCBs may disrupt pregnancy in humans.
多氯联苯（PCBs）在发育过程中的暴露会破坏动物的生殖能力。目前还缺乏人类的数据。我们测量了在 1960 年至 1963 年间收集的保存的母亲血清样本中的多氯联苯（PCBs），这些样本是在女儿出生后 1-3 天采集的。289 名女儿在 28-31 年后记录了怀孕时间（TTP）。母亲血清中的 PCB 同系物 187、156 和 99 与女儿的 TTP 延长有关，而 PCB 同系物 105、138 和 183 与 TTP 缩短有关。与母亲血清中与 TTP 延长相关的 PCB 同系物比例较高（第 75 个百分位数与第 25 个百分位数相比）的女性，怀孕的可能性下降了 38%（95%CI 17-53%），且不孕的可能性更高（13 个周期后有 30%的女性未怀孕，而 13 个周期后有 11%的女性未怀孕）。这项研究首次表明，人类在发育过程中接触多氯联苯可能会破坏妊娠。
