The Heart Research Institute, Newtown, Sydney, NSW 2042, Australia.
J Clin Biochem Nutr. 2011 Jan;48(1):8-19. doi: 10.3164/jcbn.11-006FR. Epub 2010 Dec 28.
There is considerable interest in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide range of human pathologies. This has been sparked by rapid developments in our understanding of the basic biochemistry of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of biomarkers that can be used damage induced by these oxidants in vivo, and the recent identification of a number of compounds that show promise as inhibitors of these enzymes. Such compounds offer the possibility of modulating damage in a number of human pathologies. This reviews recent developments in our understanding of the biochemistry of myeloperoxidase, the oxidants that this enzyme generates, and the use of inhibitors to inhibit such damage.
人们对哺乳动物血红素过氧化物酶（主要是髓过氧化物酶、嗜酸性粒细胞过氧化物酶和乳过氧化物酶）在广泛的人类病理中的作用产生了浓厚的兴趣。这是由于我们对这些酶的基本生物化学的理解迅速发展，对这些物种形成的氧化剂的基本化学和生物化学的理解的加深，能够用于体内检测这些氧化剂诱导的损伤的生物标志物的发展，以及最近确定了一些具有作为这些酶抑制剂的前景的化合物。此类化合物为调节多种人类病理中的损伤提供了可能。本文综述了我们对髓过氧化物酶的生物化学、该酶产生的氧化剂以及抑制剂抑制此类损伤的应用的最新认识。
