Inflammation Group, The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia.
Free Radic Res. 2009 Dec;43(12):1147-58. doi: 10.3109/10715760903214462.
Hypohalous acids (HOX), produced by peroxidase-catalysed reactions of halide and pseudohalide ions with H(2)O(2), play an important role in the human immune system. However, there is compelling evidence that these oxidants also mediate host tissue damage and contribute to the progression of a number of inflammatory diseases. Although it is well established that significant amounts of hypothiocyanous acid (HOSCN) are formed under physiological conditions, the reactions of this oxidant with host biological systems are relatively poorly characterized. It is generally accepted that HOSCN is a mild oxidant that reacts selectively with thiols. However, it is becoming increasingly recognized that this selectivity can result in the induction of significant cellular damage, which may contribute to disease. This review will outline the formation and reactivity of HOSCN and the role of this oxidant in biological systems.
次卤酸（HOX）是由过氧化物酶催化卤离子和拟卤离子与 H(2)O(2)反应生成的，在人体免疫系统中发挥着重要作用。然而，有确凿的证据表明，这些氧化剂也介导宿主组织损伤，并导致许多炎症性疾病的进展。尽管人们已经充分认识到在生理条件下会形成大量的次硫氰酸（HOSCN），但这种氧化剂与宿主生物系统的反应相对较差。人们普遍认为 HOSCN 是一种温和的氧化剂，它选择性地与硫醇反应。然而，人们越来越认识到，这种选择性可能导致显著的细胞损伤，这可能导致疾病。本综述将概述 HOSCN 的形成和反应性，以及这种氧化剂在生物系统中的作用。
