“类肉瘤样”肉芽肿性肺部疾病在世贸中心灾难救援人员中出现。
"Sarcoid like" granulomatous pulmonary disease in World Trade Center disaster responders.
机构信息
Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
出版信息
Am J Ind Med. 2011 Mar;54(3):175-84. doi: 10.1002/ajim.20924. Epub 2010 Dec 22.
BACKGROUND
More than 20,000 responders have been examined through the World Trade Center (WTC) Medical Monitoring and Treatment Program since September 11, 2001. Studies on WTC firefighters have shown elevated rates of sarcoidosis. The main objective of this study was to report the incidence of "sarcoid like" granulomatous pulmonary disease in other WTC responders.
METHODS
Cases of sarcoid like granulomatous pulmonary disease were identified by: patient self-report, physician report and ICD-9 codes. Each case was evaluated by three pulmonologists using the ACCESS criteria and only "definite" cases are reported.
RESULTS
Thirty-eight patients were classified as "definite" cases. Six-year incidence was 192/100,000. The peak annual incidence of 54 per 100,000 person-years occurred between 9/11/2003 and 9/11/2004. Incidence in black responders was nearly double that of white responders. Low FVC was the most common spirometric abnormality.
CONCLUSIONS
Sarcoid like granulomatous pulmonary disease is present among the WTC responders. While the incidence is lower than that reported among firefighters, it is higher than expected.
背景
自 2001 年 9 月 11 日以来，已有超过 20,000 名救援人员通过世界贸易中心（WTC）医疗监测和治疗计划接受了检查。对 WTC 消防员的研究表明，类肉瘤病的发病率有所上升。本研究的主要目的是报告其他 WTC 救援人员中“类肉瘤样”肉芽肿性肺部疾病的发病率。
方法
通过患者自述、医生报告和 ICD-9 代码来确定类肉瘤样肉芽肿性肺部疾病的病例。每个病例均由三位肺科医生使用 ACCESS 标准进行评估，仅报告“明确”病例。
结果
38 名患者被归类为“明确”病例。6 年的发病率为 192/100,000。发病率最高的是每年 54 例/100,000 人年，发生在 2003 年 9 月 11 日至 2004 年 9 月 11 日期间。黑人救援人员的发病率几乎是白人救援人员的两倍。肺活量（FVC）降低是最常见的肺功能异常。
结论
WTC 救援人员中存在类肉瘤样肉芽肿性肺部疾病。虽然发病率低于消防员报告的发病率，但高于预期。
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