Catinon Mickael, Cavalin Catherine, Chemarin Cécile, Rio Stéphane, Roux Elisabeth, Pecquet Mathieu, Blanchet Anne-Sophie, Vuillermoz Sylvie, Pison Christophe, Arbib François, Bonneterre Vincent, Valeyre Dominique, Freynet Olivia, Mornex Jean-François, Pacheco Yves, Freymond Nathalie, Thivolet Françoise, Kambouchner Marianne, Bernaudin Jean-François, Nathalizio Audrey, Pradat Pierre, Rosental Paul-André, Vincent Michel
Pneumology Unit and Laboratory of Mineral Pathologies, Saint Joseph and Saint Luc Hospital, Lyon, France.
Centre for European Studies, ERC Silicosis Project, Sciences Po, Paris, France.
Sarcoidosis Vasc Diffuse Lung Dis. 2018;35(4):327-332. doi: 10.36141/svdld.v35i4.7058. Epub 2020 Mar 9.
Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composition of inorganic particles was determined by energy-dispersive X-ray (EDX) spectroscopy. Dust exposure was also assessed by a specific questionnaire. Eight sarcoidosis patients and five healthy volunteers had a high dust load in their BAL. No significant difference was observed between the overall inorganic particle load of each group while a significant higher load for steel was observed in sarcoidosis patients (p=0.029). Moreover, the building activity sub-score was significantly higher in sarcoidosis patients (p=0.018). These results suggest that building work could be a risk factor for sarcoidosis which could be considered at least in some cases as a granulomatosis caused by airborne inorganic dust. The questionnaire should be validated in larger studies. .
吸入矿物粉尘被认为与结节病的发生有关。我们比较了20例结节病患者和20例匹配的健康受试者的矿物暴露组。支气管肺泡灌洗（BAL）样本经消化过滤处理后，通过透射电子显微镜进行分析。无机颗粒的化学成分通过能量色散X射线（EDX）光谱测定。还通过一份特定问卷评估粉尘暴露情况。8例结节病患者和5名健康志愿者的BAL中有高粉尘负荷。两组的总体无机颗粒负荷之间未观察到显著差异，但结节病患者的钢颗粒负荷显著更高（p=0.029）。此外，结节病患者的建筑活动分项得分显著更高（p=0.018）。这些结果表明，建筑工作可能是结节病的一个风险因素，至少在某些情况下可被视为一种由空气中无机粉尘引起的肉芽肿病。该问卷应在更大规模的研究中进行验证。
