Wu G E, Atkinson M J, Ramsden D A, Paige C J
Department of Immunology, University of Toronto, Canada.
Semin Immunol. 1990 May;2(3):207-16.
In this review, we have assembled some results on VH gene usage by mouse and human. We conclude that there is an early bias in usage of certain VH genes in both mouse and human. This biased usage has a strain dependent component as evidenced by its continued presence in the adult repertoire of some mouse strains, notably BALB/c, and not in others. The reason for the fetal bias is uncertain. However, the finding that the VH gene segments used in the human fetal repertoire are similar in sequence but not in chromosomal position to those expressed in the mouse fetal-repertoire leads us to suggest that the bias is not due to chromosomal location but rather may be reflecting the functioning of these gene products early in ontogeny.
在本综述中，我们收集了一些关于小鼠和人类VH基因使用情况的结果。我们得出结论，小鼠和人类在某些VH基因的使用上都存在早期偏向性。这种偏向性使用具有品系依赖性成分，这在一些小鼠品系（尤其是BALB/c）的成体库中持续存在而在其他品系中不存在得到了证明。胎儿期偏向性的原因尚不确定。然而，人类胎儿库中使用的VH基因片段在序列上与小鼠胎儿库中表达的VH基因片段相似，但染色体位置不同，这一发现使我们认为这种偏向性并非由于染色体位置，而是可能反映了这些基因产物在个体发育早期的功能。
