Department of Agricultural Biotechnology, Seoul National University, Seoul, South Korea.
Fertil Steril. 2011 Mar 15;95(4):1487-9. doi: 10.1016/j.fertnstert.2010.12.062.
Mature oocytes were derived from cultured preantral follicles retrieved from aged (63-67 weeks old) mice with decreased fecundity; IVF of the oocytes resulted in cleaving embryos. There was no difference in developmental competence of 4-cell embryos to the blastocyst stage between the adult and the aged groups, although general retardation of follicle development and oocyte maturation and development after IVF was detected.
从生育能力下降的老年（63-67 周龄）小鼠中取出的培养的原始卵泡中获得了成熟卵母细胞；卵母细胞的体外受精导致了分裂胚胎。尽管体外受精后卵泡发育和卵母细胞成熟和发育普遍延迟，但成年组和老年组之间的 4 细胞胚胎发育能力到囊胚阶段没有差异。
